US 10,481,096 B2 · Method of detecting single molecules

Abstract

A method of detecting single molecule includes: providing a carrier, wherein the carrier includes a substrate, and a plurality of three-dimensional nanostructures are located on the substrate; disposing single molecule samples on the plurality of three-dimensional nanostructures; detecting the single molecule samples with a detector; wherein each three-dimensional nanostructure includes a first rectangular structure, a second rectangular structure, and a triangular prism structure; the first rectangular structure, the second rectangular structure, and the triangular prism structure are stacked in that order, a first width of a bottom surface of the triangular prism structure is equal to a second width of a first top surface of the second rectangular structure and greater than a third width of a second top surface of the first rectangular structure, and the first rectangular structure comprises a first metal and the triangular prism structure comprises a second metal.

Claims14

Dependent claims

A method of detecting single molecules, the method comprising:

providing a carrier, wherein the carrier comprises a substrate, and a plurality of three-dimensional nanostructures are located on the substrate;
disposing single molecule samples on the plurality of three-dimensional nanostructures;
and
detecting the single molecule samples with a detector;
wherein each three-dimensional nanostructure comprises a first rectangular structure, a second rectangular structure, and a triangular prism structure;
the first rectangular structure is located on the substrate, the second rectangular structure is located on the first rectangular structure, the triangular prism structure is located on the second rectangular structure, a first width of a bottom surface of the triangular prism structure is equal to a second width of a first top surface of the second rectangular structure and greater than a third width of a second top surface of the first rectangular structure, and the first rectangular structure comprises a first metal and the triangular prism structure comprises a second metal.

3 more elements

A method of detecting single molecules, the method comprising:

providing a carrier, wherein the carrier comprises a substrate, and a plurality of three-dimensional nanostructures are located on the substrate;
disposing single molecule samples on the plurality of three-dimensional nanostructures;
and
detecting the single molecule samples with a detector;
wherein each three-dimensional nanostructure comprises a rectangular structure and a triangular prism structure, the rectangular structure is placed on the substrate, the triangular prism structure is located on the rectangular structure, the triangular prism structure comprises two second triangle surfaces and three rectangular surfaces, one of the three rectangular surfaces is defined as a bottom surface, a first width of the bottom surface of the triangular prism structure is greater than a second width of a top surface of the rectangular structure, the bottom surface of the triangular prism structure is in contact with the top surface of the rectangular structure, and the rectangular structure comprises a first metal and the triangular prism structure comprises a second metal, and the first metal is different from the second metal.

2 more elements

Dependencies are inferred from the claim text.

Method of detecting single molecules

Life of this patent

Method of detecting single molecules

Life of this patent

Abstract

Claims14