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US 10,480,034 B2Granted
Cancer biomarker and diagnostic
OwnerJeffrey Lordaninventor
Life of this patent
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Abstract
The application discloses new biomarkers and methods useful in the diagnosis, prognosis and/or monitoring of, or as a therapeutic or research target for, solid tumour cancers, such as colorectal cancer, based on measuring the biomarkers; and related kits and devices.
Claims16
A method for the diagnosis and/or prognosis of colorectal cancer, in a subject, wherein the method comprises:
- (i) measuring the level of ATP11B gene expression and/or the quantity protein or peptides resulting from ATP11B gene translation in a biological sample from the subject, and
- (ii) comparing the level or quantity measured in (i) with a reference value of the level of gene expression or quantity of proteins or peptides resulting from ATP11B gene translation, wherein the reference value represents a constitutive level of the gene expression and/or translation;
- wherein either:
- a) gene expression level or protein/peptide quantity at least about 40% (about 1.4-fold or more) above the reference value is indicative of a solid colorectal tumor, or
- b) a gene transcription measurement or protein/peptide quantity substantially at or similar to the reference value indicates that no colorectal cancer tumor is present, and
- (iii) treating the subject identified in (ii)(a) as having a solid colorectal tumor by administering radiotherapy or chemotherapy or carrying out surgery, or a combination thereof.
3 more elements
A method for treating colorectal cancer in a subject in need of said treatment, the method comprising:
- a) identifying the subject as in need of treatment for colorectal cancer by a method comprising:
- (i) measuring the level of ATP11B gene expression and/or the quantity protein or peptides resulting from ATP11B gene translation in a biological sample from the subject, and
- (ii) comparing the level or quantity measured in (i) with a reference value of the level of gene expression and/or the quantity of proteins or peptides resulting from ATP11B gene translation, wherein the reference value represents a constitutive level of the gene expression and/or translation;
- wherein a) an increased gene expression level or protein/peptide quantity at least about 40% (about 1.4-fold or more) above the reference value is indicative of a colorectal cancer tumor and identifies the subject as in need of treatment, and
- b) treating the subject identified as in need of treatment by administering radiotherapy or chemotherapy or carrying out surgery, or a combination thereof.
2 more elements
Dependencies are inferred from the claim text.