Recombinant AAV variants and uses thereof
AssigneeUniversity of Massachusetts
InventorsGuangping Gao, Jun Xie, Terence Flotte
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Abstract
The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
Claims11
A recombinant adeno-associated viral particle comprising an adeno-associated virus capsid and at least one heterologous transgene, wherein the adeno-associated virus capsid comprises a protein comprising an amino acid sequence selected from any one of SEQ ID NOs:
- 54 to 61.
Dependencies are inferred from the claim text.