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AssigneeThe Regents of the University of California
InventorsCheryl A. Kerfeld, Patrick Shih, Jan Zarzycki, Krishna K. Niyogi
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Methods and compositions to introduce a synthetic pathway based on the 3-hydroxypropionate bicycle into an organism such as the model cyanobacterium, Synechococcus elongatus sp. PCC 7942. The heterologously expressed pathway acts as a photorespiratory bypass as well as an additional carbon fixation cycle orthogonal to the endogenous Calvin-Benson cycle. We demonstrate the function of all six introduced enzymes, which not only has implications on increasing net-photosynthetic productivity, but also key enzymes in the pathway are involved in high-value products that are of biotechnological interest, such as 3-hydroxypropionate.
A recombinant host cell comprising heterologously expressed genes mcr, mcl, mch, mct, meh, and pcs, and a second heterologously expressed mct gene, and wherein the recombinant host cell does not naturally express the heterologously expressed genes and wherein the host cell produces a synthetic photorespiratory bypass pathway.
A recombinant host cell comprising stably transformed heterologous genes having sequences of SEQ ID Nos:
Dependencies are inferred from the claim text.