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US 10,479,998 B2Granted
RNA interference-based therapeutic against anthrax
AssigneeTexas Tech University System
InventorsMingtao Zeng, Maria T. Arevalo
Life of this patent
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Abstract
The present invention includes siRNAs and antibodies that block the interaction between TEM8 and/or CMG2 cell surface proteins and anthrax toxin and methods of treating anthrax exposure with the same.
Claims4
A method of treating an anthrax infection in a subject in need of such treatment wherein an siRNA is provided to a subject that targets the cell surface expression of a Tumor Endothelial Marker 8 (TEM8) and a capillary morphogenesis protein 2 (CMG2) cell surface protein;
- wherein the siRNA are administered to said subject in a quantity effective to reduce anthrax toxin binding to cells in the subject.
Dependencies are inferred from the claim text.