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US 10,479,868 B2Granted
Polymeric stabilizing formulations
AssigneeNano Precision Medical, Inc.
InventorsAdam Mendelsohn, Au Duong, Kathleen Fischer, Wouter Roorda
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Abstract
The present invention provides compositions of a therapeutic agent and a polymeric stabilizing agent for stabilizing the reservoir of an implantable drug delivery system. The present invention also includes an implantable drug delivery system incorporating the composition of the present invention, as well as methods of treating diabetes using the compositions and implantable drug delivery system of the present invention.
Claims31
A pharmaceutical composition comprising:
- a therapeutic agent, which therapeutic agent is a peptide, together with a polymeric stabilizing agent comprising a polymer having a plurality of stabilizing groups, wherein the polymer is a dendritic polymer or is a crossed-linked polymer, wherein said pharmaceutical composition is disposed within a reservoir of a capsule having a nanoporous membrane with a plurality of pores, the capsule configured for implantation;
- and
- the polymeric stabilizing agent comprising a polymer having a plurality of stabilizing groups having molecular dimensions larger than the pore size of the nanoporous membrane, wherein the release of the polymeric stabilizing agent from the reservoir is substantially prevented;
- and wherein the nanoporous membrane is a diffusion pathway out of the reservoir for the therapeutic agent.
1 more element
Dependencies are inferred from the claim text.