Back to results
US 10,479,865 B2Granted
Process for the preparation of sevelamer carbonate
AssigneeStrides Shasun Limited
InventorsNarayanan Sivasankaran, Iyappan Murugan, Karikalan Thangaraju, Iyyanar Kuppusamy, Uttam Kumar Ray, Tangirala Vittal
Life of this patent
Estimating the term…
Abstract
The present invention relates to a process for the preparation of Sevelamer carbonate from polyallylamine hydrochloride.
Claims18
A process for the preparation of Sevelamer carbonate, comprising:
- (a) contacting an aqueous alkaline solution of polyallylamine hydrochloride with epichlorohydrin at a pH of more than 12;
- (b) maintaining the reaction mixture obtained in step (a) under stirring until the formation of gel;
- (c) optionally washing the gel with at least one of water miscible solvent(s) and water;
- (d) suspending the obtained gel in step (b) or step (c) in water;
- (e) treating the suspension obtained in step (d) with carbon dioxide in water to obtain Sevelamer carbonate;
- and
- (f) optionally washing the Sevelamer carbonate with at least one of water miscible solvent(s) and water.
4 more elements
A process for the preparation of Sevelamer carbonate, comprising:
- (a) contacting an aqueous alkaline solution of polyallylamine hydrochloride with epichlorohydrin at a pH in the range of 13 to 14;
- (b) maintaining the reaction mixture obtained in step (a) under stirring until the formation of gel;
- (c) optionally washing the gel with isopropanol and water;
- (d) suspending the obtained gel in step (b) or step (c) in water;
- (e) treating the suspension obtained in step (d) with carbon dioxide in water to obtain Sevelamer carbonate;
- and
- (f) optionally washing the Sevelamer carbonate with methanol and water.
4 more elements
Dependencies are inferred from the claim text.