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AssigneeSorrento Therapeutics, Inc.
InventorsDingqiu Huang, Barbara A. Swanson, Heyue Zhou
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There is disclosed compositions and methods relating to or derived from anti-CXCR5 antibodies. More specifically, there is disclosed fully human antibodies that bind CXCR5, CXCR5-binding fragments and derivatives of such antibodies, and CXCR5-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having CXCR5 related disorders or conditions, including various inflammatory disorders and various cancers.
A method for treating a subject having a C-X-C Motif Chemokine Receptor 5 (CXCR5)-positive cancer, said method comprising administering an effective amount of an anti-CXCR5 polypeptide to a subject in need thereof, wherein the anti-CXCR5 polypeptide is selected from the group consisting of a recombinant fully human anti-CXCR5 antibody that binds to CXCR5, a recombinant fully human anti-CXCR5 antibody Fab fragment, and a recombinant anti-CXCR5 single chain antibody, wherein the anti-CXCR5 polypeptide comprises a heavy chain variable domain comprising the amino acid sequence of SEQ ID NO. 108, and comprises a light chain variable domain comprising the amino acid sequence of SEQ ID NO. 109.
Dependencies are inferred from the claim text.