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US 10,479,835 B2Granted
Agent, uses and methods for treatment
AssigneeH. Lundbeck A/S
InventorsLars Christian Biilmann Rønn, Ibrahim John Malik, Jeffrey B. Stavenhagen, Søren Christensen, Jan Egebjerg, Arnout Gerritsen, Edward Van Den Brink, Paul Parren, Rob De Jong
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Abstract
The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful in correcting a deficient level of progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).
Claims16
An antibody, or an antigen-binding fragment thereof, comprising:
- a) a light chain variable domain L-CDR1 comprising SEQ ID NO:
- 17;
- b) a light chain variable domain L-CDR 2 comprising SEQ ID NO:
- 18:
- c) a light chain variable domain L-CDR 3 comprising SEQ ID NO:
- 19:
- d) a heavy chain variable domain H-CDR 1 comprising SEQ ID NO:
- 20:
- e) a heavy chain variable domain H-CDR 2 comprising SEQ ID NO:
- 21:
- and
- f) a heavy chain variable domain H-CDR 3 comprising SEQ ID NO:
- 22.
10 more elements
Dependencies are inferred from the claim text.