Monoclonal antibody reacting with glycopeptide, and use thereof
AssigneeSysmex Corporation
InventorsYukiko Kataoka, Tsuyoshi Nomura, Koji Fukagawa, Yuriko Egashira, Yukiko Higa
Life of this patent
Estimating the term…
Abstract
Disclosed is a monoclonal antibody reacting with a glycopeptide, wherein the glycopeptide contains a core fucose moiety and at least 4 contiguous amino acid residues that are located on the C-terminal side of a glycosylated asparagine moiety, and both of the core fucose moiety in the glycopeptide and an amino acid residue that is located apart by at least three amino acid residues from the C-terminal of the glycosylated asparagine moiety in the glycopeptide are epitopes for the antibody.
Claims11
A monoclonal antibody, which reacts with a glycopeptide of formula (1) (SEQ ID NO:
- 13), does not react with a glycopeptide of formula (2) (SEQ ID NO:
- 14), and does not react with a glycopeptide of formula (3) (SEQ ID NO:
- 15):
- wherein said antibody comprises a heavy chain comprising three complementarity-determining regions (CDRs), which CDRs comprise the amino acid sequences of SEQ ID NOs:
- 1-3, respectively,
- and wherein said antibody further comprises a light chain comprising three CDRs, which CDRs comprise the amino acid sequences of SEQ ID NOs:
- 4-6, respectively.
A monoclonal antibody, which reacts with a glycopeptide of formula (1) (SEQ ID NO:
- 13), does not react with a glycopeptide of formula (2) (SEQ ID NO:
- 14), and does not react with a glycopeptide of formula (3) (SEQ ID NO:
- 15):
- wherein said antibody comprises a heavy chain comprising three CDRs, which CDRs comprise the amino acid sequences of SEQ ID NOs:
- 7-9, respectively,
- and wherein said antibody further comprises a light chain comprising three CDRs, which CDRs comprise the amino acid sequences of SEQ ID NOs:
- 10-12, respectively.
Dependencies are inferred from the claim text.