Utility of nematode small molecules

A method of reducing eosinophils (eos) or lymphocytes (lym), or both, in a subject, comprising:

• administering a therapeutically effective dosage of a composition to the subject, thereby reducing eos or lym, or both, in the subject,
• wherein the composition comprises a pharmaceutically acceptable carrier and a compound of Formula (I)
• wherein
• R1 is, independently for each occurrence, hydrogen or alkyl;
• R1′ is, independently for each occurrence, hydrogen or alkyl;
• X is C(R1)2;
• X1 is cis- or trans-C(R1)═C(R1);
• n1, n2, and n3 are each independently an integer of 0 to 30, inclusive;
• n4 is an integer of 1 to 30, inclusive;
• the sum of n1, each n2, and each n3 is 1 to 30, inclusive;
• R3 is hydrogen or alkyl;
• R4 is hydrogen or alkyl;
• R5′ is hydrogen, alkyl, halogen, —OR6, or —N(R6)2;
• R5 is —OR6 or —N(R6)2;
• and
• R6 is independently alkyl, alkenyl, aryl, or heteroaryl, wherein the alkyl, alkenyl, aryl, or heteroaryl is optionally substituted,
• or a pharmaceutically acceptable salt thereof.