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US 10,479,807 B2Granted
Silylated pyrimidine prodrugs and methods of their use
AssigneeEpigenetics Phrama LLC
InventorsRichard Daifuku, Dmitri S. Sergueev
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Abstract
Silylated-pyrimidine prodrugs, compositions that include the silylated-pyrimidine prodrugs, methods for making the silylated-pyrimidine prodrugs and compositions, and methods for treating cancer using the silylated-pyrimidine prodrugs and compositions.
Claims11
A compound having the formula:
- wherein R1, R2, R7, and R8 are independently selected from hydrogen or Si(R4)(R5)(R6), wherein R4, R5, and R6 are independently selected from hydrogen or alkyl, provided that at least one of R1, R2, R7, or R8 is Si(R4)(R5)(R6).
A method for delivery of a compound to a tumor site by enhanced permeability and retention, comprising administering an effective amount of a compound having the formula:
- wherein R1 and R2 are Si(CH3)3, to a tumor site in the subject in need thereof.
A method for treating a solid tumor carcinoma, comprising administering an effective amount of a compound having the formula:
- wherein R1 and R2 are Si(CH3)3, to a subject in need thereof.
Dependencies are inferred from the claim text.