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US 10,479,793 B2Granted
Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
AssigneeBristol-Myers Squibb Company
InventorsDavid S. Weinstein, Ryan M. Moslin, Yanlei Zhang, Daniel S. Gardner, Joseph B. Santella, Charles M. Langevine, Sylwia Stachura
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Abstract
Compounds of formula I or a stereoisomer or pharmaceutically-acceptable salt thereof, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
Claims3
A compound of the formula
- wherein
- R1 is —NHR2;
- R2 is C1-C6 alkyl or C3-C8 cycloalkyl;
- R3 is H, C1-C6 alkyl, hydroxy C1-C6 alkyl or mono or bicyclic C3-C8 cycloalkyl;
- R4 is H, C1-C6 alkyl, mono or bicyclic C3-C6 cycloalkyl, phenyl, or pyridyl, any of said groups other than H substituted with 0-4 R7;
- R5 is H or C1-C4 alkyl;
- R7 is H, halo, CN, CF3, C1-C4 alkyl, C1-C4 alkoxy, —CONH C1-C6 alkyl, —CONH halo C1-C6 alkyl, —CONH halo C1-C6 alkoxy, heteroaryl, or aryl, said aryl and heteroaryl groups substituted with 0-2 R8;
- R8 is H, halo, CF3, C1-C4 alkyl or C1-C4 alkoxy;
- or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.
6 more elements
Dependencies are inferred from the claim text.