Pyrido[1,2-A]pyrimidone analog, crystal form thereof, intermediate thereof and preparation method therefor
AssigneeChia Tai Tianqing Pharmaceutical Group Co., Ltd.
InventorsTao Yu, Ning Li, Lingwei Kong, Peipei Jiang, Yong Wang, Zhemin Rong, Changjun Wang, Feng Guo, Zongbin Li, Zheng Wang, Jiahu Wu, Chengde Wu
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Abstract
Disclosed in the present invention are a crystalline Form of pyrido[1,2-a]pyrimidone analog, a preparation method therefor and an intermediate thereof.
Claims17
Crystalline forms of Compound 1 as represented by the following formula or salts thereof, wherein crystalline Forms of Compound 1 or the salts thereof are selected from the group consisting of Crystalline Forms I, II, III, IV, V, VI, VII, VIII and IX:
A method for preparing Compound 1 as represented by the following formula,
- comprising the following steps,
- wherein
- X is selected from Cl or Br;
- alkali C is selected from pyridine, 2,6-lutidine, Et3N, 4-DMAP, LiOH, Cs2CO3, or K2CO3;
- solvent c is selected from pyridine, dichloromethane, toluene, acetonitrile, acetone, DMF or THF;
- a molar ratio of Compound 7 to Compound 8 is 1:1-3;
- a molar ratio of Compound 7 to alkali C is 1:1˜3.
A compound represented by the following formula, as intermediates for preparation of Compound 1,
Dependencies are inferred from the claim text.