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US 10,479,787 B2Granted
Process for preparation of tetrabenazine and deutetrabenazine
AssigneeLupin Limited
InventorsTushar Nandkumar Despande, Dnyaneshwar Tukaram Singare, Yogesh Dadaji Pawar, Yuvraj Atmaram Chavan, Purna Chandra Ray, Girij Pal Singh
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Abstract
The present invention provides process for preparation of dihydroxy benzoquinoline compound (III) comprising reacting dihydroxy isoquinoline compound (IV) or a salt thereof with (2-acetyl-4-methyl-pentyl)-trimethyl-ammonium iodide (V) and further converting it to tetrabenazine (I) and deutetrabenazine (II).
Claims19
A process for preparation of deutetrabenazine (II) comprising:
- i) obtaining dihydroxy benzoquinoline compound (III)
- by reacting dihydroxy isoquinoline compound (IV) or a salt thereof
- with (2-acetyl-4-methyl-pentyl)-trimethyl-ammonium iodide (V) or 3-methylene-5-methyl-2-hexanone (VI), and
- ii) treating dihydroxy benzoquinoline compound (III) with a source of deuteriated methyl, wherein the source of deuteriated methyl is deuteriated methanol.
1 more element
Dependencies are inferred from the claim text.