N-(pyridin-2-yl)-4-(thiazol-5-yl)pyrimidin-2-amine derivatives as therapeutic compounds

A compound of formula I shown below:

• wherein:
• z represents an optional bond such that the bond between N and the adjacent carbon atom can be a single or double bond;
• R1, R4, R6 and R7 are each independently selected from the group consisting of H, alkyl, alkyl- R10, aryl, aryl-R10, aralkyl, aralkyl-R11, halogen, NO2, CN, CF3, OH, O-alkyl, COR10, COOR10, O-aryl, O—R10, NH2, NH-alkyl, NH-aryl, N-(alkyl)2, N-(aryl)2, N-(alkyl)(aryl), NH—R10, N—(R10)(R11), N-(alkyl)(R10), N-(aryl)(R10), SH-alkyl, SH-aryl, S-(alkyl)2, S-(aryl)2, S-(alkyl)(aryl), SH—R10,S—(R10)(R11), S-(alkyl)(R10), S-(aryl)(R10), COOH, CONH2, CONH-alkyl, CONH-aryl, CON-(alkyl)(R10), CON(aryl)(R10), CONH—R10, CON—(R10)(R11), SO3H, SO2-alkyl, SO2-alkyl-R10, SO2-aryl, SO2-aryl-R10, SO2NH2, SO2NH—R10, SO2N—(R10)(R11), CF3, CO-alkyl, CO-alkyl-R10, CO-aryl, CO-aryl-R10 and R12,
• wherein said alkyl, aryl and aralkyl groups may be optionally substituted with one or more groups selected from halogen, CN, OH, O-methyl, NH2, COOH, CONH2 and CF3, and wherein when bond z is absent, R1 is taken together with R8 and is ═O or ═S;
• R2 is alkyl;
• R3 is H, C1-6 alkyl, CN or halogen;
• R5 is selected from alkyl, alkyl-R10, aryl, aryl-R10, aralkyl, aralkyl-R11, halogen, NO2, CN, CF3, OH, O-alkyl, COR10, COOR10, O-aryl, O—R10, NH2, NH-alkyl, NH-aryl, N-(alkyl)2, N-(aryl)2, N-(alkyl)(aryl), NH—R10, N—(R10)(R11), N-(alkyl)(R10), N-(aryl)(R10), SH-alkyl, SH-aryl, S-(alkyl)2, S-(aryl)2, S-(alkyl)(aryl), SH—R10, S—(R10)(R11), S-(alkyl)(R10), S-(aryl)(R10), COOH, CONH2, CONH-alkyl, CONH-aryl, CON-(alkyl)(R10), CON(aryl)(R10), CONH—R10, CON—(R10)(R11), SO3H, SO2-alkyl, SO2-alkyl-R10, SO2-aryl, SO2-aryl-R10, SO2NH2, SO2NH—R10, SO2N—(R10)(R11), CF3, CO-alkyl, CO-alkyl-R10, CO-aryl, CO-aryl-R10 and R12, wherein said alkyl, aryl and aralkyl groups may be optionally substituted with one or more groups selected from halogen, CN, OH, O-methyl, NH2, COOH, CONH2 and CF3;
• R8 is together with R1═O or ═S when bond z is absent, or is not present when bond z is present;
• R9 is H, alkyl, aryl or heterocyclic group when bond z is absent, or is not present when bond z is present;
• and
• R10, R11 and R12 are independently selected from water solubilising groups;
• or a pharmaceutically acceptable salt or solvate thereof.