Peptidyl nitril compounds as dipeptidyl peptidase I inhibitors

A compound of the formula (I)

• wherein n is 0, 1 or 2 and m is 0, 1 or 2;
• such that the sum of m and n is 1, 2, 3 or 4;
• F is fluoro;
• X1 represents
• wherein y represents 0, 1, 2, 3, 4, 5, 6, 7 or 8;
• wherein Z represents O (oxygen);
• when y is 1 or 2, then R1 independently represents deuterium;
• halogen;
• hydroxyl;
• cyano;
• oxo (═0);
• mercapto;
• or C1-3-alkyl;
• which C1-3-alkyl is optionally substituted with at least one substituent selected from halogen, hydroxyl, cyano and mercapto;
• or when y represents 3, 4, 5, 6, 7 or 8, then R1 represents deuterium;
• wherein R2 represents —C3-6-cycloalkyl, —C1-3-alkyl-C3-6-cycloalkyl or —C1-6-alkyl, which —C1-6-alkyl is optionally substituted with at least one substituent selected from hydroxyl, cyano or amino;
• as well as pharmaceutically-acceptable salts, solvates and hydrates thereof.