Aminopyrazole derivatives

A compound represented by formula (I) below:

• wherein Ar1 is C6-10 arylene or 5- to 10-membered heteroarylene optionally substituted with a group selected from Group R;
• Ar2 is C6-10 aryl or 5- to 10-membered heteroaryl optionally substituted with a group selected from Group R;
• R1 and R2 are each independently a halogen atom, C1-6 alkyl, C3-6 cycloalkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, cyano, nitro, NR5R6, OR7, SR8, SOR8, SO2R8, CONR9R10, 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q, 5- to 10-membered heteroaryl optionally substituted with a group selected from Group Q, or C6-10 aryl optionally substituted with a group selected from Group P,
• where the 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q is optionally further linked to 4- to 6-membered heterocyclyl optionally substituted with a group selected from 4- to 6-membered heterocyclyl and C6-10 aryl-C1-6 alkyl, or to C3-6 cycloalkyl through a spiro linkage;
• R5 and R6 are each independently a hydrogen atom, C1-6 alkyl optionally substituted with 4- to 6-membered heterocyclyl, amino-C1-6 alkyl, C1-6 alkylcarbonyl optionally substituted with a halogen atom, —SO2R30, —C(O)OR31, —C(O)NR32R33, 4- to 6-membered heterocyclylcarbonyl, or 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q;
• or alternatively, R5 and R6, together with the nitrogen atom to which they are bonded, form 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q;
• R7 is a hydrogen atom;
• C1-6 alkyl which optionally has, as a substituent, a group selected from amino, a halogen atom, and hydroxy;
• 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q;
• or C1-6 alkyl having, as a substituent, 4- to 10-membered heterocyclyl optionally substituted with a group selected from Group Q;
• R8 is C1-6 alkyl, halo-C1-6 alkyl, or 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q;
• R9 and R10 are each independently a hydrogen atom or C1-6 alkyl;
• or alternatively, R9 and R10, together with the nitrogen atom to which they are bonded, form 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q;
• R30 is optionally substituted C1-6 alkyl, C3-6 cycloalkyl which optionally has dihydroxy-C1-6 alkyl as a substituent, C6-10 aryl optionally substituted with a group selected from Group P, 5- to 10-membered heterocyclyl optionally substituted with a group selected from Group Q, 5- to 10-membered heteroaryl optionally substituted with a group selected from Group Q, or —NR34R35,
• where the substituent in the optionally substituted C1-6 alkyl is selected from the group consisting of a halogen atom, 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q, —C(O)NR36R37, and C6-10 aryl;
• R31 represents C1-6 alkyl which optionally has fluorene as a substituent;
• R32 and R33 are each independently a hydrogen atom, or C1-6 alkyl optionally substituted with a group selected from the group consisting of C1-6 alkoxycarbonyl and 5- to 10-membered heteroaryl;
• or alternatively, R32 and R33, together with the nitrogen atom to which they are bonded, form 4- to 6-membered heterocyclyl;
• R34 and R35 are each independently a hydrogen atom, C1-6 alkyl optionally substituted with a group selected from hydroxy and C1-6 alkoxy, 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q, C3-6 cycloalkyl, or C1-6 alkoxy;
• or alternatively, R34 and R35, together with the nitrogen atom to which they are bonded, form 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q;
• R36 and R37 are each independently a hydrogen atom, C1-6 alkyl, or 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q;
• or alternatively, R36 and R37, together with the nitrogen atom to which they are bonded, form 4- to 6-membered heterocyclyl optionally substituted with a substituent selected from Group Q;
• Group P is a halogen atom, cyano, hydroxy, —NR50R51, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxycarbonyl, 5- to 10-membered heteroaryl, and or C1-6 haloalkyl;
• where R50 and R51 are each independently a hydrogen atom or C1-6 alkyl;
• Group Q is cyano, a halogen atom, C1-6 alkyl which optionally has a substituent, C1-6 alkoxy, C3-6 cycloalkyl, 4- to 6-membered heterocyclyl which optionally has oxo as a substituent, C1-6 alkylcarbonyl, C1-6 alkylsulfonyl, C3-6 cycloalkylsulfonyl, C1-6 alkyloxycarbonyl, amino-C1-6 alkylcarbonyl, oxo, thioxo, hydroxy, or —NR52R53;
• where the substituent in the C1-6 alkyl which optionally has a substituent selected from a halogen atom, hydroxy, 5- to 10-membered heteroaryl, and C6-10 aryl, where the C6-10 aryl optionally has hydroxy as a substituent;
• R52 and R53 each independently represents a hydrogen atom, C1-6 alkyl, C1-6 alkylsulfonyl which may have optionally has a halogen atom as a substituent, C6-10 arylsulfonyl, C6-10 aryl-C1-6 alkylsulfonyl, or —C(O)OR54,
• R54 represents C1-6 alkyl which optionally has a group selected from phenyl, fluorene, and 5- to 10-membered heteroaryl as a substituent;
• and
• Group R is a halogen atom, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, nitro, or —NR60R61 {where R60 and R61 are identical or different, and are each a hydrogen atom, optionally substituted C1-6 alkyl (in which the substituent is hydroxy, C1-6 alkoxycarbonyl, carboxyl, or carboxamide), or amino-C1-6 alkyl;
• or alternatively, R60 and R61, together with the nitrogen atom to which they are bonded, form a 4- to 6-membered heterocycle},
• or a pharmaceutically acceptable salt thereof.