Phosphatidylinositol 3-kinase inhibitors

A compound having the structure of formula (I):

• wherein:
• R1 is selected from:
• n is 1, 2, 3 or 4;
• s is 1, 2 or 3;
• t is 1 or 2;
• each X1, X2, X3, X4, X5, X6 and X7 is independently selected from C and N;
• R2 is selected from hydrogen, halo, cyano, hydroxy, amino, —C(O)Ra, —C(O)ORb, —C(O)NRaRb, —N(Ra)C(O)Rb, —S(O)NRaRb, —S(O)2NRaRb, —S(O)Rg, —S(O)2Rg, —NRaRb, —ORa, —SRb, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S, and 4-10 membered heterocyclyl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S,
• wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl and 4-10 membered heterocyclyl of R2 is optionally substituted with one to four R101;
• R3 is selected from halo, cyano, hydroxy, amino, —C(O)Ra, —C(O)ORb, —C(O)NRaRb, —N(Ra)C(O)Rb, —N(Ra)C(O)NRaRb, —OC(O)NRaRb, —NRaS(O)2NRaRb, —NRaS(O)2Ra, —N(Ra)C(O)NRaRb, —OC(O)NRaRb, —NRaS(O)2NRaRb, —NRaS(O)2Ra, —S(O)NRaRb, —S(O)2NRaRb, —S(O)Rg, —S(O)2Rg —NRaRb, —ORa, —SRb, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S, and 4-10 membered heterocyclyl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S,
• wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl and 4-10 membered heterocyclyl of R3 is optionally substituted with one to four R102;
• R4 is selected from 5-10 membered heteroaryl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S, and 4-10 membered heterocyclyl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S,
• wherein each 5-10 membered heteroaryl and 4-10 membered heterocyclyl of R4 is optionally substituted with one to four R103;
• each R5 is independently selected from hydrogen, halo, cyano, hydroxy, amino, —C(O)Ra, —C(O)ORb, —C(O)NRaRb, —N(Ra)C(O)Rb, —N(Ra)C(O)NRaRb, —N(Ra)C(O)NRaRb, —OC(O)NRaRb, —NRaS(O)2NRaRb, —NRaS(O)2Ra, —OC(O)NRaRb, —NRaS(O)2NRaRb, —NRaS(O)2Ra, —S(O)NRaRb, —S(O)2NRaRb, —S(O)Rg, —S(O)2Rg, —NRaRb, —ORa, —SRb, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S, and 4-10 membered heterocyclyl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S,
• wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl and 4-10 membered heterocyclyl of R5 is optionally substituted with one to four R104;
• each R6 is independently hydrogen, halo, cyano, hydroxy, amino, —C(O)Ra, —C(O)ORb, —C(O)NRaRb, —N(Ra)C(O)Rb, —S(O)NRaRb, —S(O)2NRaRb, —S(O)Rg, —S(O)2Rg, —NRaRb, —ORa, —SRb, C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl;
• each R7 is independently selected from hydrogen, halo, cyano, hydroxy, amino, —C(O)Ra, —C(O)ORb, —C(O)NRaRb, —N(Ra)C(O)Rb, —S(O)NRaRb, —S(O)2NRaRb, —S(O)Rg, —S(O)2Rg, —NRaRb, —ORa, —SRb, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S, and 4-10 membered heterocyclyl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S,
• wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl and 4-10 membered heterocyclyl of R7 is optionally substituted with one to four R100;
• each Ra and Rb is independently selected from hydrogen, C6-10 aryl, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl;
• wherein each C1-6 alkyl, C2-6 alkynyl of Ra and Rb, C2-6 alkynyl, is optionally substituted with one to four R200;
• each R100, R101, R102, R103 and R104 is independently selected from hydrogen, halo, cyano, hydroxy, amino, oxo, thioxo, vinyl, —C(O)Rc, —C(O)ORc, —C(O)NRcRd, —N(Rc)C(O)Rd, —N(Rc)C(O)NRcRd, —N(Rc)C(O)NRcRd, —OC(O)NRcRd, —NRcS(O)2NRcRd, —NRcS(O)2Rc, —OC(O)NRcRd, —NRcS(O)2NRcRd, —NRcS(O)2Rc, —S(O)NRcRd, —S(O)2NRcRd, —S(O)Rc, —S(O)2Rg, —NRcRd, —ORc, —SRd, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl and 4-10 membered heterocyclyl,
• wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl and 4-10 membered heterocyclyl of R100, R101, R102, R103 and R104 is optionally substituted with one to four R201, and
• each Rc and Rd is independently selected from hydrogen, C6-10 aryl, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl;
• each R200 and R201 is independently selected from hydrogen, halo, cyano, hydroxy, amino, oxo, thioxo, vinyl, —C(O)Re, —C(O)ORe, —C(O)NReRf, —N(Re)C(O)Rf, —S(O)NReRf, —S(O)2NReRf, NReRf, —ORe, —SRe, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl,
• each Re and Rf is independently selected from hydrogen, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl;
• and
• each Rg is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S, and 4-10 membered heterocyclyl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S,
• wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl and 4-10 membered heterocyclyl of Rg is optionally substituted with one to four R200,
• or a pharmaceutically acceptable salt, double bond isomer, racemate, stereoisomer, enantiomer, diastereomer, or atropisomer thereof.