Movement disorder therapy system, devices and methods, and intelligent methods of tuning

A movement disorder therapy system comprising:

• a movement disorder diagnostic device comprising at least one physiological or movement sensor adapted to be worn, attached or held at different locations on the surface of the subject's body and having a signal related to a subject's motion, the movement disorder diagnostic device adapted to provide therapy to a subject with a deep brain stimulation (DBS) device operable with adjustable DBS parameters, and to measure movement data based at least in part on the signal of the at least one sensor while the subject performs at least one movement disorder test, the movement disorder diagnostic device further comprising at least one electronic component adapted to collect and transmit the measured movement data;
• a processor comprising a quantification algorithm and a determination algorithm, the processor adapted to, at least in part, extract at least one kinematic feature from the measured movement data, the quantification algorithm adapted to receive data corresponding to the subject's measured motor symptoms and the at least one extracted kinematic feature and to quantify motor symptoms of the subject based thereon, and the determination algorithm adapted to provide a suggested level of DBS parameters based on a mode of therapy or treatment corresponding to the subject's needs based at least in part on the quantified motor symptoms;
• a data output comprising data corresponding to the subject's measured and quantified motor symptoms and/or the suggested DBS parameters, the data output adapted to be displayed visually for review by a clinician, physician, or technician to determine a second level of DBS parameters for a tuning output based on the data output;
• and
• the tuning output adapted to interface with the subject's DBS device to provide the second level of DBS parameters for the subject's DBS device to alter the subject's symptomatic movement and to be entered into the subject's DBS device such that the subject's DBS device operates under the second level of DBS parameters,
• wherein the at least one kinematic feature is selected from the group consisting of peak power angular velocity, peak power angle, RMS angular velocity, frequency, maximum amplitude, maximum peak-to-peak amplitude, mean angular velocity, and wavelet parameters, peak power acceleration, peak power velocity, peak power position, RMS acceleration, RMS velocity, RMS position, mean acceleration, wavelet parameters, covariance of any of the kinematic features, and standard deviation over time of any of these kinematic features.

A movement disorder therapy system comprising:

• a movement disorder diagnostic device comprising at least one physiological or movement sensor adapted to be worn, attached or held at different locations on the surface of the subject's body and having a signal related to a subject's motion, the movement disorder diagnostic device adapted to provide therapy to a subject with a deep brain stimulation (DBS) device operable with adjustable DBS parameters, and to measure movement data based at least in part on the signal of the at least one sensor while the subject performs at least one movement disorder test, the movement disorder diagnostic device further comprising at least one electronic component adapted to collect and transmit the measured movement data;
• a processor comprising a quantification algorithm and a determination algorithm, the processor adapted to, at least in part, extract at least one kinematic feature from the measured movement data, the quantification algorithm adapted to receive data corresponding to the subject's measured motor symptoms and the at least one extracted kinematic feature and to quantify motor symptoms of the subject based thereon, and the determination algorithm adapted to provide a second level of DBS parameters based on a mode of therapy or treatment corresponding to the subject's needs based at least in part on the quantified motor symptoms;
• and
• a tuning output adapted to interface with the subject's DBS device to provide the second level of DBS parameters for the subject's DBS device to alter the subject's symptomatic movement and to be automatically entered into the subject's DBS device such that the subject's DBS device operates under the second level of DBS parameters,
• wherein the quantification algorithm includes and artificial neural network, a Bayesian network, and/or a genetic algorithm.