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AssigneeUniversity of the Witwatersrand, Johannesburg
InventorsViness Pillay, Yahya Essop Choonara, Pradeep Kumar, Lisa Claire Du Toit, Poornima Ramburrun
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This invention relates to biodegradable implants comprising a hydrogel carrier matrix having dispersed therein a multitude of particles, wherein each of the multitude of particles and/or the hydrogel carrier matrix includes an active pharmaceutical ingredient (API) for the treatment of transected peripheral nerve injuries. Each of the multitude of particles and/or the hydrogel carrier matrix includes pristine polymer particles, preferably the pristine polymer particles may be polymethylmethacrylate polymers and derivatives thereof, preferably poly(methacrylic-co-methyl methacrylate) (PMMA). The spheroidal particles may each be formed from an outer shell including a chitosan (CHT) poly(methacrylic-co-methyl methacrylate) (PMMA) polyelectrolyte complex (CHT-PMMA-PEC) and an inner core including crosslinked chitosan having dispersed therein PMMA nanoparticles.
A biodegradable implant comprising a hydrogel carrier matrix having dispersed therein a multitude of spheroidal particles, each spheroidal particle including a crosslinked cationic chitosan (CHT) having dispersed therein anionic poly(methacrylic-co-methyl methacrylate) (PMMA) nanoparticles, and wherein the hydrogel carrier matrix comprises at least one anionic polysaccharide.
Dependencies are inferred from the claim text.