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US 10,478,524 B2Granted
Tissue-engineered silk organs
AssigneeTrustees of Tufts College
InventorsDavid L. Kaplan, Fiorenzo G. Omenetto, Jeffrey K. Marchant, Noorjahan Panjwani, Brian Lawrence
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Abstract
This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.
Claims8
A grooved substrate comprising silk fibroin,
- wherein thickness of the substrate ranges from 10 nm to 1 mm,
- wherein groove width is at least 125 nm, and
- wherein the substrate comprises micropores,
- wherein spacing between the micropores is 50 μm to 100 μm and,
- wherein an average diameter of the micropores ranges from 100 nm to 10 μm.
2 more elements
Dependencies are inferred from the claim text.