Peptide-based multiple-drug delivery vehicle

A process of preparing a molecular structure represented by Formula I:

• wherein:
• AA1 and AAn are each independently an amino acid residue;
• n is an integer equal to or larger than 2 and denoting the number of said amino acid residues in the structure;
• TM is a targeting moiety;
• L0, L11, L12, Ln1 and Ln2 are each independently a linking moiety;
• D1, Dn and Dn+1 are each independently a bioactive agent or absent, provided that at least two of D1, Dn and Dn+1 are each independently a bioactive agent;
• and
• at least one bioactive agent of said D1, Dn and Dn+1 is different than at least one other bioactive agent of said D1, Dn and Dn+1, the process comprising:
• binding a targeting moiety to a solid support;
• linking said AA1 to said targeting moiety;
• optionally attaching said D1 to said AA1;
• linking AA2 to said AA1;
• optionally attaching D2 to said AA2;
• optionally attaching D2+1 to said AA2;
• when n is larger than 2, linking said AAn to said AA2;
• optionally attaching Dn to said AAn;
• optionally attaching Dn+1 to said AAn;
• and
• detaching said targeting moiety from said solid support to thereby obtain the molecular structure.