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US 10,478,506 B2Granted
Fucoidan nanogels and methods of their use and manufacture
AssigneeMemorial Sloan Kettering Cancer Center
InventorsAdriana Haimovitz-Friedman, Daniel A. Heller, Yosef Shamay
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Abstract
Described herein are polymeric drug-carrying nanogels that are capable of targeting to P-selectin for the treatment of cancer and other diseases and conditions associated with P-selectin. Furthermore, in certain embodiments, the nanogels presented here offer a drug release mechanism based on acidic pH in the microenvironment of a tumor, thereby providing improved treatment targeting capability and allowing use of lower drug doses, thereby reducing toxicity.
Claims20
A polymeric nanoparticle with affinity to P-selectin, the nanoparticle comprising a non-covalent assembly of
- a sulfated polymer species comprising free hydroxyl moieties and free sulfate moieties capable of targeting P-selectin, the sulfated polymer species comprising one or more of a sulfated polysaccharide, a protein, or a fucoidan;
- a hydrophobic drug;
- and
- a dye comprising a fluorophore;
- wherein
- the nanoparticle has an intensity-weighted average diameter as determined by dynamic light scattering of about 20 nm and about 200 nm;
- and
- the non-covalent assembly is a self-assembly of the sulfated polymer species around the hydrophobic drug.
5 more elements
Dependencies are inferred from the claim text.