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US 10,478,504 B2Granted
Tamper resistant pharmaceutical formulations
AssigneePurdue Pharma L.P.
InventorsDebora Guido, Haiyong Hugh Huang
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Abstract
Disclosed in certain embodiments is a solid oral dosage form comprising a heat-labile gelling agent; a thermal stabilizer; and a drug susceptible to abuse.
Claims14
A solid oral dosage form comprising
- a heat-labile gelling agent;
- a thermal stabilizer comprising an anionic polymer in a neutral pH aqueous solution;
- and
- a drug susceptible to abuse,
- wherein the solid oral dosage form releases at least about 85% of the drug susceptible to abuse within 45 minutes as measured by in-vitro dissolution in a USP Apparatus 2 (paddle) at 50 rpm in 500 ml SGF at 37° C.
2 more elements
Dependencies are inferred from the claim text.