Methods for enhancing the efficacy of a tumor-directed immune response
AssigneeAugusta University Research Institute, Inc.
InventorSamir Khleif
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Abstract
As described below, the present invention features methods for enhancing the efficacy of a tumor antigen in inducing an anti-cancer immune response in a subject by administering an OX40 agonist and an Indoleamine 2,3-dioxygenase (IDO) inhibitor with the tumor antigen.
Claims3
A method for enhancing an immune response against a tumor antigen in a subject, the method comprising administering to the subject an OX40 agonist antibody or an antigen-binding fragment thereof, 1-methyltryptophan (1-MT), and an immunogenic composition comprising an HPV antigen, thereby enhancing the subject's immune response against the tumor antigen relative to administration of the immunogenic composition and the OX40 agonist antibody or an antigen-binding fragment thereof.
A method for delaying or reducing tumor growth in a subject, the method comprising administering to the subject an OX40 agonist antibody or an antigen-binding fragment thereof, 1-methyltryptophan (1-MT) and an immunogenic composition comprising an HPV antigen, thereby delaying or reducing tumor growth in the subject relative to administration of the immunogenic composition and the OX40 agonist antibody or an antigen-binding fragment thereof.
Dependencies are inferred from the claim text.