Liposomal flu vaccine formulation
AssigneeSouthwest Research Institute
InventorsXingguo Cheng, Kenneth H. Carson, Joseph A. McDonough, Renukaradhya J. Gourapura, Chang Won Lee, Santosh Dhakal
Life of this patent
Estimating the term…
Abstract
The present invention relates to the field of pharmaceutical and vaccine formulations. More specifically, formulations which comprise an antigen comprising a mixture of oligopeptides loaded into liposome nanoparticles, optionally including an adjuvant, to provide an improved immune response.
Claims19
An immunogenic composition comprising:
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 1;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 2;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 3;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 4;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 5;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 6;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 7;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 8;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 9;
- and
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 10.
An immunogenic composition comprising:
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 1;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 2;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 3;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 4;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 5;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 6;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 7;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 8;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 9;
- and
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 10;
- and
- an adjuvant comprising mono sodium urate present at a level of 1.0 mg to 10.0 mg.
A method for eliciting an immune response and conferring protection against influenza virus in a subject, wherein the method comprises administering to the subject a vaccine comprising:
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 1;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 2;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 3;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 4;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 5;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 6;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 7;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 8;
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 9;
- and
- an oligopeptide consisting of the sequence set forth by SEQ ID NO:
- 10;
- to elicit an immune response and confer protection against influenza virus.
Dependencies are inferred from the claim text.