US 10,478,483 B2Granted

Combinations of meningococcal factor H binding proteins

AssigneeGlaxosmithkline Biologicals SA

InventorsMaria Aricò, Brunella Brunelli, Maurizio Comanducci, Mariagrazia Pizza, Silvana Savino, Maria Scarselli

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Abstract

The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence.

Claims10

Dependent claims

An immunogenic composition which comprises an immunologically effective amount of an adjuvant, an immunologically effective amount of a first isolated factor H binding protein (fHbp) antigen and an immunologically effective amount of a second isolated fHbp antigen, wherein:

the first isolated fHbp antigen comprises a first amino acid sequence which has at least 75% sequence identity to both of SEQ ID NO:
1 and SEQ ID NO:
23, but the first amino acid sequence has a higher sequence identity to SEQ ID NO:
1 than to SEQ ID NO:
23, when aligned using the same algorithm and parameters;
and the second isolated fHbp antigen comprises a second amino acid sequence which has at least 75% sequence identity to both of SEQ ID NO:
1 and SEQ ID NO:
23, but the second amino acid sequence has a higher sequence identity to SEQ ID NO:
23 than to SEQ ID NO:
1, when aligned using the same algorithm and parameters.

7 more elements

Dependencies are inferred from the claim text.

Facts

Application: 13/806,743Filed 24 Jun 2011 · us provisional application
Priority: 25 Jun 2010
Published: US 2013/0189295 A125 Jul 2013
Granted: 19 Nov 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification8 codes

A61K 39/095
Bacterial antigens: neisseria
A61K 39/385
Medicinal preparations containing antigens or antibodies: haptens or antigens, bound to carriers
A61K 39/39
Medicinal preparations containing antigens or antibodies: characterised by the immunostimulating additives, e.g. chemical adjuvants
A61P 31/04
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antibacterial agents

Family

Application61/358,816Us provisional application · filed 25 Jun 2010
US 2013/0189295 A1Pre-grant publication · published 25 Jul 2013
US 10,478,483 B2This patent

From the US filing history. Foreign family members aren’t listed.

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