Compositions and methods of using anti-mullerian hormone for treatment of infertility
AssigneesThe Center for Human Reproduction (Chr), University of Rochester
InventorsAritro Sen, Norbert Gleicher, Vitaly A. Kushnir
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Abstract
The present invention provides compositions and methods for the treatment of subjects with impaired fertility or at risk for impaired fertility. In certain aspects, the invention relates to increasing the level or activity of anti-Mullerian hormone (AMH) in a subject.
Claims8
A method for treating infertility in a subject comprising administering to the subject an effective amount of a composition comprising anti-Mullerian hormone (AMH), wherein the AMH comprises the amino acid sequence set forth in SEQ ID NO:1;
- and wherein the AMH is administered at a dose in the range of about 22,000 ng/day to about 44,000 ng/day for a period of time from about 30 days to about 90 days.
A method of increasing the number of collected oocytes during superovulation in a subject, the method comprising:
- a) administering to the subject an effective amount of AMH each day for a first period of time;
- b) inducing superovulation in the subject after a second period of time where no AMH is delivered to the subject, wherein the AMH comprises the amino acid sequence set forth in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.