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AssigneeSociete des Produits Nestle S.A.
InventorsSophie Helene Nutten, Nanda De Groot, Valerie Francoise Verhasselt
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This invention relates to the administration of a combination of TGF-β and one or more peptides comprising specific sequences of β-lacto-globulin. The peptides are hypoallergenic but retain the capability to induce tolerance to the native protein. The combination of TGF-β and one or more of these peptides has the therapeutic effect of inducing and maintaining oral tolerance towards newly introduced proteins, in particular, at the weaning period. The combination can modulate the infant and toddler immune response to allergens.
A method for induction and maintenance of oral tolerance to β-lactoglobulin (BLG) and maintenance of oral tolerance to other food proteins that has been acquired via consumption of maternal mill in a young mammal during and after weaning period, the method comprising administering to the young mammal a composition comprising at least eight different peptides;
A method for primary prevention of allergic reactions to milk proteins and to electedly introduced dietary protein in a young mammal during and after weaning, the method comprising administering to the young mammal a composition comprising at least eight different peptides, each having a length from five to twelve amino adds that comprises a sequence selected from SEQ ID No. 1-8, and the composition further comprising TGF-β-β), wherein each of SEQ NOs:
Dependencies are inferred from the claim text.