External-use medicament for cleaning and care of the ovaries, vagina, and vulva

An external-use composition effective for cleaning and caring for ovaries, vagina and vulva, wherein the external-use composition effectively inhibits or prevents repeated infection of the ovaries, the composition comprising therapeutically effective amounts of the following, by parts by weight of the composition:

• propolis extract in an amount of 1 to 10 parts by weight,
• zedoary oil in an amount of 5 to 10 parts by weight, and
• mint leaf filtrate in an amount of 50 to 100 parts by weight,
• wherein the external-use composition is a medical liquid composition prepared by a method comprising:
• preparing the propolis extract, including:
• loading raw propolis into a CO2 extraction tank and circularly adding CO2 liquid to perform extraction with an extraction temperature of 15 to 30° C., an extraction pressure of 8 to 10 MPa, and extraction time of 1 to 2 hours, to obtain the propolis extract, a propolis content of which is 1% to 3% of amount of the raw propolis;
• preparing the zedoary oil, including:
• directly loading zedoary seeds into a CO2 extraction tank and circularly adding CO2 liquid to perform extraction with an extraction temperature of 20 to 30° C., an extraction pressure of 2 to 7 MPa, and extraction time of 1 to 2 hours, to obtain zedoary oil extract containing a plant zedoary ketone ingredient;
• preparing the mint leaf filtrate, including:
• mixing fresh mint leafs with pure water in a weight ratio of 1:2 to 1:3, breaking the fresh mint leafs in water mechanically into pieces, adding medical ethanol of 0.1 to 0.2 times by weight, soaking for 10 to 15 hours, and filtrating with a 200 mesh screen to remove precipitates to obtain the mint leaf filtrate;
• dissolving the propolis extract, the zedoary oil extract and the mint leaf filtrate, in accordance with requirements of the formula composition, into medical ethanol of 0.1 to 0.3 times by weight of the active ingredients, and mixing them, and then removing by freezing and centrifugation, precipitates under the following conditions:
• at a frozen temperature of 0° C. to 4° C. and at a centrifugal rotation speed of 3000 rpm to 4000 rpm, for a duration of 10 to 20 minutes, and then separating centrifugate by an acoustic membrane separator to obtain a medical liquid with a molecular weight less than 10000D,
• obtaining the external-use composition, and
• optionally bottling or bagging the external-use composition.