Therapeutic use of tetrathiomolybdate
AssigneeUCL Business PLC
InventorsMervyn Singer, John Francis Martin, Alex Peter Dyson
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Abstract
Tetrathiomolybdate is for use in therapy of a condition requiring reduced metabolism of an organ or whole body, e.g. myocardial infection, stroke or ischaemia-reperfusion injury.
Claims13
A method for acute treatment of ischemia-reperfusion injury (IRI) in a subject that has undergone ischemic injury and is now at risk for acute injury caused by reperfusion following said ischemic injury, wherein said method comprises administering, to said subject, tetrathiomolybdate (TTM), via continuous infusion, wherein a total dose of up to 20 mg/kg TTM is administered to the subject over a period of one hour or less, such that within two hours of initiating treatment with TTM, there occurs in the subject a decrease in at least one of oxygen consumption and carbon dioxide production, thereby providing acute treatment of said IRI.
Dependencies are inferred from the claim text.