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AssigneeEndorecherche, Inc.
InventorsMohamed El-Alfy, Fernand Labrie, Louise Berger
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Novel methods for treating or reducing the likelihood of acquiring vaginal dysfunctions, more particularly vaginal dryness and dyspareunia, leading to sexual dysfunction and low sexual desire and performance, in susceptible warm-blooded animals including humans involving administration of a sex steroid precursor. Further administration of estrogen or selective estrogen receptor modulator, particularly those selected from the group consisting of Raloxifene, Arzoxifene, Tamoxifen, Droloxifene, Toremifene, Iodoxifene, GW 5638, TSE-424, ERA-923, and lasofoxifene, and more particularly compounds having the general structure: is specifically disclosed for the medical treatment and/or inhibition of development of some of these above-mentioned diseases. Pharmaceutical compositions for delivery of active ingredient(s) and kit(s) useful to the invention are also disclosed.
A method of treating or reducing the likelihood of acquiring a vaginal disease or condition caused by the atrophy of either or both of the layer lamina propria and/or the layer muscularis of the vagina in postmenopausal women, wherein said disease or condition is sexual dysfunction other than dyspareunia, said method comprising administering a sex steroid precursor that is dehydroepiandrosterone, to a patient in need of said treatment and also administering to said patient, as part of a combination therapy, a selective estrogen receptor modulator that is:
Dependencies are inferred from the claim text.