Pharmaceutical compositions for inhibiting angiogenesis comprising plant-derived natural compound
AssigneeIndustry-Academic Cooperation Foundation, Yonsei University
InventorsHo Jeong Kwon, Yong Hyo Kim
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Abstract
The present invention provides a pharmaceutical composition for inhibiting angiogenesis containing a plant-derived natural compound which can be effective for preventing or treating disorders or diseases associated with angiogenesis. The compound used as an active ingredient in the pharmaceutical composition of the present invention suppresses VEGF-induced angiogenic responses without cytotoxicity at a low concentration by inhibiting the expression of an anti-angiogenic factor (for example, VEGF), and thus remarkably improves the safety of a drug.
Claims3
A method for treating cancer selected from the group consisting of lung cancer, breast cancer, pancreatic cancer, thyroid cancer, and glioblastoma the method comprising administering to a subject in need thereof, a composition comprising as an active ingredient a compound represented by Chemical Formula 1 below:
- wherein, R1, R2, and R3 each are independently hydrogen, C1-12 alkyl, C1-12 alkoxy, hydroxy, CN, CONH2, halo, oxazolyl, C1-12 alkylthio, or trifluoro(C1-2) alkyl.
Dependencies are inferred from the claim text.