Unit dose of an aryl sulfonamide that is effective for treating eye disease and averting potential vision loss

A unit dose containing an effective amount of a compound having the following formula, or a pharmaceutically effective salt thereof;

• wherein the unit dose is formulated as a pharmaceutical composition in an excipient in a volume suitable for intraocular administration into an eye of a subject in need thereof;
• wherein the amount of the compound in the unit dose renders the unit dose effective for treating an ophthalmic disease or disorder in the eye that is not a cancer.

A unit dose of a pharmaceutical composition in a formulation for intravitreal administration into an eye of a subject in need thereof;

• wherein the pharmaceutical composition contains the compound (R)—N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)-4-((4-(4-hydroxypiperidin-1-yl)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide, or a pharmaceutically acceptable salt thereof,
• wherein the formulation of the composition, an amount of the compound, and a volume of the unit dose configure the unit dose to be safe and effective for removing p16-positive senescent cells that are not cancer cells from the eye of the subject.