Therapeutic agent for fibrosis and inhibitor of nuclear translocation of phosphorylated smad
AssigneeNational University Corporation Chiba University
InventorsHiroyuki Nakamura, Toshihiko Murayama
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Abstract
A therapeutic agent for fibrosis, whose active ingredient is constituted by a glucosylceramide synthase inhibitor or lactosylceramide synthase inhibitor, or both, inhibits the nuclear translocation of phosphorylated Smad, thereby treating and preventing fibrosis.
Claims3
A method for treating fibrosis caused by nuclear translocation of phosphorylated Smad, wherein the fibrosis is idiopathic pulmonary fibrosis, comprising administrating a therapeutic agent for the fibrosis whose active ingredient is constituted by a glucosylceramide synthase inhibitor or lactosylceramide synthase inhibitor, or both, which inhibitor has the activity of inhibiting nuclear translocation of phosphorylated Smad and is contained in a therapeutically effective amount, said inhibitor(s) being a sole inhibitor or sole inhibitors administrated during and for treatment of the fibrosis.
Dependencies are inferred from the claim text.