Formulation for effective tocotrienol delivery
AssigneeKl-Kepong Oleomas Sdn Bhd
InventorsChee Wai Fong, Yee Wei Ung, Jordan Todorov Petkov
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Abstract
The present invention disclosed a formulation in the form of self-emulsifying drug delivery formulation for improved delivery of tocotrienols comprising a fat-soluble compound, at least one emulsifier, and an oil carrier. The formulation shows an improved bioavailability of tocotrienols.
Claims13
A method of delivering a tocotrienol to a subject in need of supplementing an intake of a daily allowance of a fat-soluble nutrient, the method comprising administering to the subject a dietary supplement comprising a self-emulsifying formulation comprising a fat-soluble compound selected from tocotrienols and derivatives thereof, wherein the amount of the fat-soluble compound is about 10% to about 50%, by weight of the formulation;
- two emulsifiers each selected from the group consisting of nonionic surfactants, wherein the emulsifiers are sorbitan monolaurate and polyoxyethylene sorbitan 20 monooleate (Polysorbate 80), wherein the amount of emulsifiers is about 15% to about 45%, by weight of the formulation, wherein the weight ratio of said sorbitan monolaurate to Polysorbate 80 is about 1:1 to about 1:20;
- and
- an oil carrier selected from the group consisting of glycerides, wherein the amount of oil carrier is about 6% to about 56%, by weight of the formulation.
Dependencies are inferred from the claim text.