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US 10,478,402 B2Granted
Solid nanoparticle with inorganic coating
AssigneeNanexa AB
InventorsJan-Otto Carlsson, Anders Johansson, Marten Rooth
Life of this patent
Estimating the term…
Abstract
A nanoparticle having a solid core comprising a biologically active substance, said core being enclosed by an inorganic coating, a method for preparing the nanoparticle, and the use of the nanoparticle in therapy. A kit comprising the nanoparticle and a pharmaceutical composition comprising the nanoparticle.
Claims29
A method of preparing a controlled or delayed release pharmaceutical composition comprising:
- i. a plurality of coated particles of a size that is from 0.1 μm to 50 μm, said coated particles having a solid core comprising a biologically active substance, said solid core being enclosed by one or more metal oxide materials;
- and
- ii. a pharmaceutically acceptable carrier,
- the method comprising the sequential steps of:
- (1) applying an initial coating of at least one metal oxide to said solid cores in an atomic layer deposition reactor;
- (2) discharging the coated particles from the reactor and subjecting the coated particles to agitation to disaggregate particle aggregates formed during step (1);
- (3) reintroducing the disaggregated, coated particles from step (2) into an atomic layer deposition reactor and applying a further coating of at least one metal oxide to the reintroduced particles;
- (4) optionally repeating steps (2) and (3) one or more times to increase total thickness of the one or more metal oxide materials that enclose said solid core;
- and
- (5) admixing said coated particles obtained from step (3) or step (4) with said pharmaceutically acceptable carrier to form said pharmaceutical composition.
7 more elements
A controlled or delayed release pharmaceutical composition comprising:
- i. a plurality of coated particles of a size that is from 0.1 μm to 50 μm, said coated particles having a solid core comprising a biologically active substance, said solid core being enclosed by one or more metal oxide materials to enable a therapeutically effective controlled or delayed release of the biologically active substance from the coated particles in said pharmaceutical composition;
- and
- ii. a pharmaceutically acceptable carrier,
- the pharmaceutical composition being prepared according to a process comprising the sequential steps of:
- (1) applying a coating of at least one metal oxide to said solid cores in an atomic layer deposition reactor;
- (2) discharging the coated particles from the reactor and subjecting the coated particles to agitation to disaggregate particle aggregates formed during step (1);
- (3) reintroducing the disaggregated, coated particles from step (2) into an atomic layer deposition reactor and applying a further coating of at least one metal oxide to the reintroduced particles;
- (4) optionally repeating steps (2) and (3) one or more times to increase total thickness of the one or more metal oxide materials that enclose said solid core;
- and
- (5) admixing said coated particles obtained from step (3) or step (4) with said pharmaceutically acceptable carrier to form said pharmaceutical composition
- wherein the controlled or delayed release of the biologically active substance from the coated particles is provided by the process steps (1) to (3) and (4), if performed.
8 more elements
Dependencies are inferred from the claim text.