Methods for tissue passivation
AssigneeThe General Hospital Corporation
InventorsWilliam G. Austen, Jr., Michael McCormack, Robert W. Redmond, Irene E. Kochevar
Life of this patent
Estimating the term…
Abstract
Methods of tissue passivation are described herein for use in preserving normal tissue architecture, reducing post-surgical inflammation, and reducing or preventing the development of pathogenic collagen bundles and adhesions following surgical procedures. Passivated tissues prepared in accordance with these methods are useful in a variety of therapies including, e.g., cardiac bypass surgery, hemodialysis, etc.
Claims29
A method of preventing or decreasing intimal hyperplasia within a human blood vessel, the method comprising exposing an intact, non-proliferative, exterior surface of the human blood vessel to a cross-linking tissue structure stabilizing agent (“TSSA”) that does not penetrate beyond an external layer of collagen in the exterior surface under conditions sufficient to promote cross-linking of proteins within the exterior vascular surface while preserving normal tissue architecture of regions of the human blood vessel beyond the external layer of collagen, thereby preventing or decreasing intimal hyperplasia within the human blood vessel.
A method of preventing or decreasing scarring, fibrotic response, or contracture within a dissected cavity in a human subject, the method comprising:
- topically applying a cross-linking tissue structure stabilizing agent (“TSSA”) to at least a non-proliferative, uninjured internal connective tissue surface of a dissected abdominal, thoracic, or chest cavity under conditions sufficient to promote cross-linking of proteins within the non-proliferative, uninjured internal connective tissue surface of the dissected abdominal, thoracic, or chest cavity, thereby preventing or decreasing scarring, fibrotic response, or contracture while otherwise preserving normal tissue architecture within the dissected abdominal, thoracic, or chest cavity.
A method of preventing or decreasing tissue adhesion and/or contracture within a dissected cavity in a human subject, the method comprising:
- topically applying a photoactive cross-linking tissue structure stabilizing agent (“TSSA”) to at least a non-proliferative, uninjured internal connective tissue surface of a dissected cavity;
- irradiating the photoactive cross-linking TSSA under conditions sufficient to promote cross-linking of proteins within the internal connective tissue surface of the dissected cavity while otherwise preserving normal tissue architecture, thereby preparing a non-adhesive internal connective tissue surface;
- implanting natural or synthetic materials within the dissected cavity;
- and
- closing the dissected cavity.
Dependencies are inferred from the claim text.