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US 10,478,132 B2Granted
Glucose conjugated gold nanoparticle
AssigneeBar-Ilan University
InventorsRachela Popovtzer, Menachem Motiei, Tamar Dreifuss
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Abstract
Composition methods and kits for diagnosing and treating tumors within a subject. The compositions disclosed comprise: a gold nanoparticle; PEG or derivatives thereof, wherein said PEG or derivatives thereof have a molecular weight of 400 to 1500 Dalton; and a 2-Deoxy-D-glucose, wherein the PEG or derivatives thereof are linked to the gold nanoparticle and to said 2-Deoxy-D-Glucose, and wherein the 2-Deoxy-D-Glucose is linked to the PEG or derivatives thereof at the 2-Carbon position of the 2-Deoxy-D-Glucose.
Claims18
A composition comprising:
- a gold nanoparticle;
- PEG or derivatives thereof, wherein said PEG and derivatives thereof have a molecular weight of 400 to 1000 Dalton;
- and
- a 2-Deoxy-D-glucose,
- wherein said PEG or derivatives thereof are linked to said gold nanoparticle and to said 2-Deoxy-D-Glucose, wherein said PEG or derivatives thereof are linked to said gold nanoparticle via a chemical attachment selected from the group consisting of:
- covalent attachment, semi-covalent attachment and non-covalent attachment,
- wherein said 2-Deoxy-D-Glucose is linked to said PEG and derivatives thereof at the 2-Carbon position of said 2-Deoxy-D-Glucose;
- and
- wherein said composition has a diameter of 20 to 60 nanometers.
6 more elements
Dependencies are inferred from the claim text.