Early detection of reduced bone formation with an NMR scanner
AssigneeRamot at Tel-Aviv University Ltd.
InventorsUri Nevo, Itzhak Binderman, Yifat Sarda, Elad Bergman
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Abstract
A method for early detection of bone deficiency in a patient, comprising: collecting NMR signals of a bone marrow volume in a bone of the patient having normal bone density levels which are not indicative of bone deficiency as indicated by X-ray; and analyzing said collected NMR signals to detect at least a presence or absence of a preclinical stage of bone deficiency in said bone.
Claims13
A method for monitoring treatment of bone deficiency in a patient, comprising:
- collecting NMR signals of a bone marrow volume in a bone of the patient, at a first time point, using a stray field non-homogeneous NMR scanner;
- repeating the collecting of NMR signals at least at a second time point, at least six weeks after the first time point;
- the patient receiving a treatment for bone deficiency, between the first time point and the second time point;
- analyzing the NMR signals collected at the first time point and the second time point, comprising estimating one or both of adipose tissue content and changes in adipose tissue content of the bone marrow, providing feedback on the treatment.
A method for monitoring treatment of bone deficiency in a patient, comprising:
- collecting NMR signals of a bone marrow volume in a bone of the patient, at a first time point, without applying imaging pulses to the bone marrow volume;
- repeating the collecting of NMR signals at least at a second time point, at least six weeks after the first time point;
- the patient receiving a treatment for bone deficiency, between the first time point and the second time point;
- analyzing the NMR signals collected at the first time point and the second time point, comprising estimating one or both of adipose tissue content and changes in adipose tissue content of the bone marrow, providing feedback on the treatment.
A method for monitoring treatment of bone deficiency in a patient, comprising:
- collecting NMR signals of a bone marrow volume in a bone of the patient, at a first time point;
- repeating the collecting of NMR signals at least at a second time point, at least six weeks after the first time point;
- the patient receiving a treatment for bone deficiency, between the first time point and the second time point;
- analyzing the NMR signals collected at the first time point and the second time point, comprising using one or both of a ratio between T1 and T2 and a ratio between T1 and T2* to indicate changes in adipose tissue content of the bone marrow, providing feedback on the treatment.
Dependencies are inferred from the claim text.