High osmolarity antimicrobial composition containing one or more organic solvents
AssigneeNext Science IP Holdings Pty Ltd
InventorMatthew Franco Myntti
Life of this patent
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Abstract
A composition that can solvate biofilms and disrupt bacterial cell walls acts to both kill the bacteria by cell lysis and remove the biofilm. This solvent-containing composition is effective against a broad spectrum of microbes and can be used on a variety of surfaces, both living and inanimate. The polarity of the solvent component of the composition is lower than that of pure water so that the composition exhibits increased efficacy in solvating the macromolecular matrix of a biofilm and in penetrating bacterial cell walls.
Claims20
An antimicrobial composition adapted for dermal application, said composition comprising (a) a carrier base and (b) a liquid composition exhibiting an effective solute concentration of at least about 0.75 Osm/L and a pH of at least 3, wherein said liquid composition consists of
- (1) a solvent component that exhibits a δp value of no more than 14.4 MPa1/2 and consists of water, one or more C1-C16 acyclic alcohols and, optionally, glycerol;
- and
- (2) a solute component that comprises cationic surfactant and dissociation products of at least two organic acids.
A composition adapted for dermal application, said composition comprising:
- a) a carrier base and
- b) a liquid composition which exhibits an effective solute concentration of at least about 0.65 Osm/L and a pH of from 3.5 to 5.5, wherein said liquid composition consists of
- 1) a solvent component that exhibits a δp value of no more than 14.4 MPa1/2 and consists essentially of water, 2-propanol and, optionally, glycerol;
- and
- 2) a solute component that comprises benzalkonium chloride, dissociation products of at least one monoprotic acid and at least one polyacid, and dissociation product of a salt of one of said at least one polyacid.
Dependencies are inferred from the claim text.