US 10,464,902 B1 · Multi-tyrosine kinase inhibitors derivatives and methods of use

Abstract

The present invention is directed to multi-tyrosine kinase inhibitor compounds. The present invention is further directed to compositions comprising those compounds. Finally, the present invention is directed to methods of treating eye conditions including, but not limited to, diabetic background retinopathy, diabetic macular edema, diabetic proliferative retinopathy, diabetic macular edema with proliferative retinopathy, proliferative fibrovascular disease, diabetic macular edema with proliferative fibrovascular disease, retinopathy of prematurity, dry macular degeneration, dry macular degeneration with drusen and wet macular degeneration, using compounds and compositions of the invention.

Claims2

Dependent claims

A compound selected from

wherein X is a peptide, a protein or absent.

Dependencies are inferred from the claim text.

Facts

Application

15/812,399Filed 14 Nov 2017 · continuation in part

Priority

29 Jun 2015

Granted

5 Nov 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification4 codes

C07D 215/22
Oxygen atoms: attached in position 2 or 4
C07D 215/48
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…
C07D 413/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
C07D
Heterocyclic compounds

Family

Application62/185,785Us provisional application · filed 29 Jun 2015

Application15/194,813Parent of this continuation-in-part · filed 28 Jun 2016

Application15/288,820Parent of this continuation-in-part · filed 7 Oct 2016

Application15/402,214Parent of this continuation-in-part · filed 9 Jan 2017

Application15/403,139Parent of this continuation-in-part · filed 10 Jan 2017

Application15/676,060Parent of this continuation-in-part · filed 14 Aug 2017

Application15/711,208Parent of this continuation-in-part · filed 21 Sep 2017

US 2016/0376239 A1Published application

US 2017/0020856 A1Published application

US 2017/0112821 A1Published application

US 2017/0143688 A1Published application

US 2017/0342033 A1Published application

US 2018/0009758 A1Published application

US 10,464,902 B1This patent

From the US filing history. Foreign family members aren’t listed.

Multi-tyrosine kinase inhibitors derivatives and methods of use

Life of this patent

Multi-tyrosine kinase inhibitors derivatives and methods of use

Life of this patent

Abstract

Claims2