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US 10,457,913 B2Granted
Corneal epithelioid cells derived from surface ectodermal cells
AssigneeOsaka University
InventorsKohji Nishida, Yuzuru Sasamoto, Ryuhei Hayashi
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Abstract
The present invention relates to a method for inducing a keratin 12-positive corneal epithelioid cell from a surface ectoderm-derived cell. More specifically, the present invention relates to a method for inducing a keratin 12-positive corneal epithelioid cell, comprising introducing PAX6, KLF4, and OCT4 into a surface ectoderm-derived cell, such as an oral mucosal epithelial cell, and a corneal epithelioid cell induced by the method.
Claims7
An in vitro or ex vivo method for producing a keratin-12 positive human corneal epithelioid cell, comprising:
- introducing a lentiviral vector comprising nucleic acids encoding PAX6, KLF4, and OCT4 into a human epithelial cell,
- wherein expression of the lentiviral vector induces the production of a keratin 12-positive human corneal epithelioid cell.
Dependencies are inferred from the claim text.