Systems and methods for opening of a tissue barrier in primates
AssigneeThe Trustees of Columbia University in the City of New York
InventorsElisa E. Konofagou, Fabrice Marquet, Yao-Sheng Tung
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Abstract
Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions.
Claims12
A method for cavitation-guided opening of a targeted region of tissue within a primate skull, comprising:
- delivering one or more microbubbles to proximate the targeted region;
- applying an ultrasound beam using a transducer, through the skull of the primate to the targeted region to open the tissue;
- transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue;
- determining a cavitation spectrum from the acquired acoustic emissions;
- determining whether a vessel is located between the ultrasound beam and the targeted region or proximate to the targeted region based on the cavitation spectrum;
- and
- determining a cavitation signal-to-noise ratio (SNR) from the acquired acoustic emissions, wherein the cavitation SNR is a ratio of post- to pre-microbubble cavitation doses.
Dependencies are inferred from the claim text.