Method and system for cancer treatment with radiation
AssigneeDalhousie University
InventorsR. Lee MacDonald, Christopher G. Thomas, James Leonard Robar
Life of this patent
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Abstract
Embodiments generally relate to cancer treatment with radiation sources. The present technology discloses techniques that can enable an automatic generation of radiotherapy trajectories using anatomical data of a patient. It can improve conformal dose distributions and target volume coverage by considering a radiation risk decided by an organs-at-risk (OAR)'s relative location to the target volume and the radiation source.
Claims26
A non-transitory computer-readable storage medium including instructions that, when executed by at least one processor of a computing device, cause the computing device to:
- receive anatomical imaging data of one or more organs-at-risk and a target volume;
- determine a two-dimensional, radiation-beam's-eye-view (BEV) centered on the target volume for each of a plurality of gantry positions;
- for each BEV for the plurality of gantry positions, calculating a foreground/background weighting factor, the foreground/background weighting factor indicating a risk of exposing a respective organ-at-risk within the BEV as a function of a relative position of the respective organ-at-risk with respect to the target volume and the radiation source;
- and
- determine a preferred gantry position from the plurality of gantry positions by:
- calculating a respective overlapping volume for the one or more organs-at-risk for each BEV for the plurality of gantry positions multiplied by the foreground/background weighting factor.
A system for determining a trajectory of a radiation source in radiotherapy, comprising:
- a radiation source associated with a gantry angle;
- a patient support system associated with a patient support angle;
- one or more computer systems configured to:
- receive anatomical imaging data of one or more organs-at-risk and a target volume;
- determining a two-dimensional, radiation-beam's-eye-view (BEV) centered on a target volume for each of a plurality of gantry positions;
- calculate a respective foreground/background weighting factor for each BEV of the plurality of gantry positions, the foreground/background weighting factor indicating a risk of exposing a respective organ-at-risk within the BEV as a function of the relative position of the organ-at-risk with respect to the target volume and the radiation source;
- calculate a respective overlapping volume for the each of the one or more organs-at-risk at each suitable gantry angle and each suitable patient support angle;
- modify the respective overlapping volume of the each of the one or more organs-at-risk based at least in part on the respective foreground/background weighting factor and a radiation sensitivity weighting factor associated with each of the one or more organs-at-risk;
- generate a geometric overlap map for the one or more organs-at-risk by summing the modified overlapping volume of the each of the one or more organs-at-risk;
- and
- generate a radiation trajectory using the geometric overlap map.
A computer-implemented method for determining a trajectory of a radiation source in radiotherapy, comprising:
- receiving anatomical imaging data of one or more organs-at-risk and a target volume;
- determining a two-dimensional, radiation-beam's-eye-view (BEV) centered on the target volume for each of a plurality of gantry positions;
- for each BEV for the plurality of gantry positions, calculating a foreground/background weighting factor, the foreground/background weighting factor indicating a risk of exposing a respective organ-at-risk within the BEV as a function of a relative position of the respective organ-at-risk with respect to the target volume and the radiation source;
- determining a preferred gantry position from the plurality of gantry positions by:
- calculating a respective overlapping volume for the one or more organs-at-risk for each BEV for the plurality of gantry positions multiplied by the foreground/background weighting factor;
- generating a geometric overlap map for the one or more organs-at-risk from the respective overlapping volume for the one or more organs-at-risk for each BEV;
- and
- generating a radiation trajectory using the geometric overlap map.
Dependencies are inferred from the claim text.