Treatment of conditions susceptible to pulsed electromagnetic field therapy

A method of treating painful peripheral diabetic neuropathy (PPDN) in a patient in need thereof comprising:

• administering a plurality of PEMF treatments to the patient over a treatment period, each of the plurality of PEMF treatment comprising applying the PEMF treatment to a treated foot of the patient with a pulse frequency of about 1000 Hz and a pulse width of about 42 μs;
• promoting an increased nerve density in the treated foot over the treatment period by administering the PEMF treatment;
• modulating nerve function in the treated foot over the treatment period by administering the PEMF treatment;
• and
• producing a decrease in a pain score reported by the patient over the treatment period, by administering the PEMF treatment.

A method of modulating wound healing in a cell of a treated tissue of a patient in need thereof comprising:

• applying a PEMF treatment to the treated tissue of the patient, the PEMF treatment comprising a pulse frequency of about 1000 Hz and a pulse width of about 42 μs;
• and
• modulating expression of one of an HO-1, COX-2, ALOX-12, ALOX-15, PTGDS, PTGES, PTGIS, NOX, CAT, GSR, PRDX-6, and SOD-3 gene in the cell of the treated tissue;
• and
• measuring a first wound volume at a first time and a second wound volume at a second time;
• wherein the cell is one of a dermal fibroblast cell, an epidermal keratinocyte cell, and a human monocyte cell;
• wherein expression of one of the HO-1, COX-2, ALOX-12, ALOX-15, PTGDS, PTGES, PTGIS, NOX, CAT, GSR, PRDX-6, and SOD-3 genes in the cell of the treated tissue is susceptible to the PEMF treatment;
• and
• wherein the PEMF treatment produces a decrease in a wound volume between the first wound volume and the second wound volume.