US 10,441,757 B2 · Drug-coated balloon

Abstract

Described here are devices, systems, and methods for treating conditions or diseases of the nose, ear, or throat with an expandable device having a drug coating. The expandable devices may be delivered to a body cavity in a low-profile configuration and expanded to contact surrounding tissue. The expandable devices may deliver or release the drug coating to the tissue. Multiple expansions of a single device may be employed during treatment. Various coating excipients and manufacturing parameters for the expandable devices may also be adjusted to enhance or slow transfer of the drug coating and/or release of the drug to the target tissue site. The drug transferred to the tissue may act as an in situ depot that enables maintenance of a therapeutic level of locally delivered drug for a desired time period after removal of the expandable devices.

Claims47

Dependent claims

A method of treating a nasal, otic, or throat condition, comprising:

providing an expandable device comprising a drug coating on an external surface thereof and having a low-profile configuration and an expanded configuration;
delivering the expandable device in the low-profile configuration to a target tissue site;
transferring the drug coating from the external surface to the target tissue site over multiple expansions of the expandable device, wherein transfer of the drug coating is controlled during each expansion;
removing the expandable member from the target tissue site;
and
maintaining a therapeutic level of local drug delivery at the target tissue site from the transferred drug coating for a time period effective to treat the target tissue site.

3 more elements

Dependencies are inferred from the claim text.

Drug-coated balloon

Life of this patent

Drug-coated balloon

Life of this patent

Abstract

Claims47