Monitoring a physiological parameter associated with tissue of a host to confirm delivery of medication

A method of treating a host with a medication, the method comprising:

• providing a medication delivery device which deliver the medication into a tissue of the host, wherein the medication delivery device includes a sensor, and wherein the sensor is used to measure a physiological parameter of the tissue;
• introducing the medication delivery device including the sensor into the tissue such that the tissue is in contact with the sensor;
• delivering the medication into the tissue of the host;
• forming a depot in the tissue with the medication, the depot formed such that the sensor is at least partially within the depot with the depot disposed between the sensor and the tissue, wherein the depot is disposed between the sensor and the tissue such that the depot reduces the tissue contact with the sensor;
• confirming delivery of the medication from the medication delivery device to the host, wherein confirming delivery of the medication comprises using the sensor to measure the physiological parameter of the tissue within a predetermined time period after delivery of the medication and while the sensor is at least partially within the depot with the depot disposed between the sensor and the tissue.