PET solutions and methods of making PET solutions for medical devices

A method for making an implantable medical device including a poly(ethylene terephthalate) layer, the method comprising:

• formulating a poly(ethylene terephthalate) solution by dissolving poly(ethylene terephthalate) in a solvent mixture to form a solution, the solvent mixture consisting of a first solvent component and a second solvent component, wherein a solubility of the poly(ethylene terephthalate) in the solvent mixture is at least about 2 wt. % at a temperature from about 20° C. to about 25° C., wherein a Hansen Solubility Parameter Distance between the solvent mixture and HSP coordinates having a dispersion HSP of 18.02 MPa0.5, a polar HSP of 5.56 MPa0.5, and a hydrogen bonding HSP of 14.27 MPa0.5 is less than about 2 MPa0.5;
• depositing the poly(ethylene terephthalate) solution onto the implantable medical device;
• and
• drying the implantable medical device and evaporating the solvent mixture to leave behind the poly(ethylene terephthalate) layer, wherein the first solvent component of the composition is (E)-cinnamyl alcohol and the second solvent component is dl-lactic acid;
• the first solvent component is 2-phenoxy ethanol and the second solvent component is thymol;
• the first solvent component is 2-allylphenol and the second solvent component is dl-lactic acid;
• the first solvent component cis 4-propylphenol and the second is dl-lactic acid;
• the first solvent component is trans anethole and the second solvent component is dl-lactic acid;
• the first solvent component is benzyl alcohol and the second solvent component is ethylene glycol, iso-butanol, or 1-butanol;
• the first solvent component is chavicol and the second solvent component is dl-lactic acid;
• the first solvent component is cinnamyl alcohol and the second solvent component is 2-methyl-1,3-butanediol, 1-butanol, 2-propanol, or 3-methyl allyl alcohol;
• the first solvent component is dihydroeugenol and the second solvent component is dl-lactic acid;
• the first solvent component is hawthorn carbinol, and the second solvent component is dl-lactic acid;
• the first solvent component is hawthorn ethanol and the second solvent component is dl-lactic acid;
• the first solvent component is isopropenylphenol and the second solvent component is dl-lactic acid;
• the first solvent component is n-butyl salicylate and the second solvent component is dl-lactic acid or ethylene glycol;
• the first solvent component is peony alcohol and the second solvent component is dl-lactic acid;
• or the first solvent component is thymol and the second solvent component is 2,3-butanediol, 2-methyl-1,3-butanediol, or 2-hydroxy-2-methylpropanoic acid.